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Data from:Tata 1mg · Learn more Mirtazapine Tablets (Mirtazapine): Uses, Dosage, Side Mirtazapine: Side effects, dosage, uses, and more Mirtazapine: 7 things you should know - Drugs.com Mirtazapine: Uses, side effects, warnings, and interactions Many drugs can affect mirtazapine, especially: cimetidine; diazepam; St. John's wort; tramadol; tryptophan (sometimes called L-tryptophan); an antibiotic - clarithromycin, rifampin, rifampicin, telithromycin; antifungal medicine - itraconazole, ketoconazole; antiviral medicine to treat HIV/AIDS -. Mirtazapine is an antidepressant medication that works in the brain. It is approved for the treatment of major depressive disorder (MDD). Symptoms of depression include: Depressed mood - feeling sad, empty, or tearful Feeling worthless, guilty, hopeless, and helpless Loss of interest or pleasure in your usual activities Mirtazapine is an antidepressant that doctors prescribe to treat depression. 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